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a history of bladder cancer;

FDA pregnancy category C. It is not known whether Actos will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. See also: Pregnancy and breastfeeding warnings (in more detail)
congestive heart failure or heart disease;

Use Actos regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.



Breastfeeding Warnings


changes in your vision; or
Your pharmacist can provide more information about Actos.


It is not known whether pioglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.


Important information
Overview



Side Effects





sudden unusual pain in your hand, arm, or foot.
This list is not complete and many other medicines may increase or decrease the effects of Actos on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Actos only for the indication prescribed.

What happens if I overdose?

Actos (pioglitazone) is an oral diabetes medicine that helps control blood sugar levels.

Support Group Q & A
Tell your doctor if you use insulin. Taking Actos while you are using insulin may increase your risk of serious heart problems.
Some women using Actos have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.


More Pregnancy Warnings

Before taking this medicine
Common Actos side effects may include:
More about Actos (pioglitazone) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Espanol 32 Reviews - Add your own review/rating Generic Availability
You should not use Actos if you are allergic to pioglitazone, or if you have severe or uncontrolled heart failure, or bladder cancer. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).


Where can I get more information?
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Call your doctor at once if you have:
Generic Name: pioglitazone (oral) (PYE o GLIT a zone) Brand Names: Actos
Consumer resources Actos Actos (Advanced Reading) Professional resources Actos (AHFS Monograph) Actos (FDA) Related treatment guides Nonalcoholic Fatty Liver Disease Diabetes, Type 2
Add to My Med List


Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

rifampin; or

Take Actos exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
fluid retention;

Can Prescription Drugs Lead to Weight Gain?

Interactions
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Taking this medicine may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with Actos.

Actos is not for treating type 1 diabetes.



Actos is usually taken once daily. You may take the medicine with or without food.



Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking Actos. Talk with your doctor if you are concerned about this possibility.
Slideshow

Actos is for people with type 2 diabetes.

See also: Side effects (in more detail) What other drugs will affect Actos?

Actos can cause or worsen congestive heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

Do not give this medicine to anyone under 18 years old without medical advice. Actos should not be given to a child.
Stop using Actos and call your doctor at once if you have symptoms of liver damage: nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
gemfibrozil;


Actos side effects
liver disease.
Actos is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

other oral diabetes medications, such as acetohexamide, chlorpropamide, glimepiride, glipizide, tolbutamide.

How should I take Actos?







Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.


You should not use Actos if you have severe or uncontrolled heart failure, or if you have bladder cancer. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Actos is not for treating type 1 diabetes.

pink or red urine, painful or difficult urination, urinating more than usual;

Professional
a history of heart attack or stroke; or
See also: Dosage Information (in more detail) What happens if I miss a dose?
shortness of breath (even with mild exertion), swelling, rapid weight gain;
Drug Images
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Actos, especially:

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.
muscle pain; or
Dosage

headache;


Actos may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.
What should I avoid?

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.
Pricing & Coupons
User Reviews

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Get emergency medical help if you have any of these signs of an allergic reaction to Actos: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
What is Actos?



To make sure Actos is safe for you, tell your doctor if you have:


This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

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