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What other drugs will affect tadalafil?

Once daily use for ED and Benign Prostatic Hyperplasia (BPH):
Slideshow
-Maintenance dose: 2.5 to 5 mg orally once a day based on individual efficacy and tolerability.



seizure (convulsions); or
How should I take tadalafil?

Tadalafil may also be used for purposes not listed in this medication guide.
Adcirca (R):
Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor.





Tadalafil can be taken with or without food.
-5 mg orally once a day at approximately the same time, without regard to timing of sexual activity
Comment: Dividing the 40 mg dose over the course of the day is not recommended.




Use: Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)


Cialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.
Usual Adult Dose for Benign Prostatic Hyperplasia:
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis);
If you take tadalafil every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
For erectile dysfunction, take Cialis just before sexual activity but not more than once per day.

Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.
Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Once daily use for BPH:

a recent history (in the past 6 months) of a stroke, or congestive heart failure;

swelling in your hands, ankles, or feet;
Drinking alcohol with this medicine can cause side effects.

More Pregnancy Warnings

Comment: Consider that this drug has shown to improve erectile dysfunction up to 36 hours following dosing, when used as needed.
Tadalafil relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body.

Generic Name: tadalafil (ta DAL a fil) Brand Names: Adcirca, Cialis

heart disease or heart rhythm problems, coronary artery disease;
-40 mg orally once a day
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-Initial dose: 2.5 mg orally once a day at approximately the same time, without regard to timing of sexual activity

-5 mg orally once a day at approximately the same time, for up to 26 weeks
What happens if I overdose?
vision changes or sudden vision loss; or




You should not take tadalafil if you are allergic to it, or:


Interactions



Once daily use for ED and BPH:
To make sure tadalafil is safe for you, tell your doctor if you have any of these other conditions:


Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tadalafil only for the indication prescribed.
if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas).




muscle pain.

This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Professional

drugs to treat high blood pressure or a prostate disorder; or

liver or kidney disease (or if you are on dialysis);
Dosage




sinus pain, sore throat; or




headache;
angina (chest pain), high or low blood pressure;


Important information
Usual Adult Dose for Erectile Dysfunction:
shortness of breath;


Common tadalafil side effects may include:



More about tadalafil Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Espanol 383 Reviews - Add your own review/rating Consumer resources Tadalafil Tadalafil (Advanced Reading) Other brands: Cialis , Adcirca Professional resources Tadalafil (AHFS Monograph) Tadalafil (Wolters Kluwer) Related treatment guides Erectile Dysfunction Benign Prostatic Hyperplasia Pulmonary Hypertension
-Initial dose: 10 mg orally once a day, as needed, prior to sexual activity

Overview
if you have been told you should not have sexual intercourse for health reasons.
Use as needed for ED:




It is not known whether tadalafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.



See also: Side effects (in more detail) Tadalafil dosing information




Some medicines can cause unwanted or dangerous effects when used with tadalafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).
Tell your doctor about all your current medicines and any you start or stop using, especially:
-Maintenance dose: 5 to 20 mg orally once a day, as needed, prior to sexual activity based on individual efficacy and tolerability


Tadalafil is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Store at room temperature away from moisture and heat.
Do not break or split a Cialis tablet. Swallow it whole.


User Reviews
-5 mg orally once a day at approximately the same time, without regard to timing of sexual activity
Tadalafil side effects
a stomach ulcer;
This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Cialis: 7 Important Things You Need to Know
Stop using tadalafil and get emergency medical help if you have:
seizure medicine.

Tadalafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking Viagra or other drugs similar to tadalafil. Most of these people also had certain pre-existing eye problems or risk factors for blood vessel disorders (such as heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether tadalafil is the actual cause of vision loss.
Stop using tadalafil and get emergency medical help if you have sudden vision loss.
Also call your doctor right away if you have:
a recent heart attack (within the past 90 days);




retinitis pigmentosa (an inherited condition of the eye);

Your pharmacist can provide more information about tadalafil.


Get emergency medical help if you have any signs of an allergic reaction to tadalafil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Side Effects

Concomitant administration with finasteride:
Support Group Q & A
Before taking this medicine

a bleeding disorder such as hemophilia;

Use: Treatment of erectile dysfunction (ED)

a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;



antiviral medicine to treat hepatitis C or HIV/AIDS;
Comments: The incremental benefit of this drug decreases from 4 weeks until 26 weeks. The incremental benefit of this drug beyond 26 weeks is unknown.

See also: Dosage Information (in more detail) What happens if I miss a dose?
-5 mg orally once a day at approximately the same time


Do not take Cialis while also taking Adcirca, unless your doctor tells you to.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of tadalafil.
If tadalafil is used as needed, you are not likely to be on a dosing schedule.
Where can I get more information?
Usual Adult Dose for Pulmonary Hypertension:





diarrhea;






Once a day use for ED:

Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.
Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.
Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What is tadalafil?

ringing in your ears, or sudden hearing loss;

a light-headed feeling, like you might pass out.
irregular heartbeat;
an antibiotic or antifungal medicine;
a physical deformity of the penis (such as Peyronie's disease); or
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